Family Planning Plus

Irregular spotting and bleeding can be side effects of the DepoProvera injection. The injections work by stopping ovulation and by thinning the uterine lining. This effect on the uterine lining is what helps decrease, and frequently stop, period bleeding. Even if shots are consistently on time, it does not completely stop the build up of uterine lining. Therefore, some bleeding or spotting may occur at one time or another. The length of time the bleeding lasts will just depend on how thick the lining is. This usually resolves on its own.

Irregular bleeding can be a sign of a vaginal infection or STD. If you have multiple partners  or your partner has other sexual partners, you may want to consider having an STD screening. If your bleeding continues after your next injection, talk to your doctor or clinic about your options.